You have been forwarded to a temporary system while our US-based webserver is being rebuild. Please note that you will not be able to retrieve results from this system that were uploaded to cadd.gs.washington.edu. If you would like to score variants, you have to upload them to this temporary system.
Supplementary Materials of "A general framework for estimating the relative pathogenicity of human genetic variants" by Kircher & Witten et al. 2014
The script for generating simulated single nucleotide and indel variants as well as the parameter files used to simulate the variants for the above manuscript are available for download here. This software is released under a MIT license (license text available from the ZIP-archive). Please see the README file contained in the ZIP-archive for further information about the software.